Taking Tianeptine: Benefits, Risks, and How to Use

If you’ve been following the world of nootropics for some time, you’ve likely heard about tianeptine.

Tianeptine is a drug used for depression in some Asian, European, and Latin American countries. Some of the claimed tianeptine benefits included reduced anxiety and depression and enhanced cognitive function.

But what are the risks, and how should you use this drug? In this post, we’ll take a closer look at antidepressant tianeptine: what it is, what benefits it offers, and how to use it safely and effectively.


Why do people take tianeptine?

Tianeptine is a novel antidepressant agent with a unique neurochemical profile. Tianeptine has been shown to treat major depression, dysthymia, and bipolar disorder. Tianeptine is also for anxiety disorders, including panic disorder and social anxiety disorder. Tianeptine has a low incidence of side effects and is well tolerated by most patients. Tianeptine is an attractive option for the treatment of depression and anxiety disorders

Some of the indications people are prescribed to use tianeptine are the following:

  • Feeling bad about themselves
  • Feeling sad
  • Poor appetite or sleep
  • Feeling useless or hopeless

Tianeptine may also be indicated for other health conditions. Check with a health care professional if you’re unsure why you are prescribed to take this medication.

5 Tianeptine Benefits

1. Helps relieve depressive symptoms

Tianeptine is a novel antidepressant that has been shown to be as effective and safe as selective serotonin reuptake inhibitors (SSRIs) and other classic treatments for depression. It also reduces the risk of relapse or recurrence in patients with chronic conditions like this. Thus, making it an important drug candidate against major depressive disorders.

Moreover, it is a medication with the potential to treat specific subgroupings of depressed individuals, such as elderly patients or those suffering from chronic alcoholism. This drug’s minimal adverse effect profile makes it an attractive option for these clients, who might otherwise be prescribed more heavily sedating medications that pose greater risks when taken together with others.

Tianeptine is a drug that has been shown in a clinical trial to improve the quality of life for people with Parkinson’s disease. It reduces symptoms like depression and improves cognitive function. The study also found that as depression improved, so did anxiety and somatic symptoms. It also appeared to decrease the severity of melancholia.

In another study performed involving postmenopausal women, tianeptine was found effective in the treatment of emotional disturbances. This drug may also decrease appetite. However, long-term treatment with tianeptine does not appear to alter body weight to the desired extent. Thus, it should not be used as the sole treatment for obesity.

2. Improves cognitive functioning in depressed people

A study that compared the neurocognitive effects of tianeptine and escitalopram in patients with major depressive disorder revealed that tianeptine offered significantly better performance on attention, working memory, and executive function than escitalopram. Tianeptine was also associated with less cognitive impairment than escitalopram. These findings suggest that tianeptine may be a better option than escitalopram for depressed patients who are concerned about the cognitive side effects of antidepressants.

Another study concluded that tianeptine could improve cognitive functioning in depressed individuals. Patients treated with this drug had enhanced performance in tests that measure the learning process and short-term memory, including attention and reaction time.

3. Reduces the frequency of asthma attacks

During an asthma attack, chemicals like catecholamines and free serotonin circulate in the blood. In a pilot study, tianeptine has been shown to decrease free serotonin in the blood. It enhances serotonin uptake by platelets and serotonergic brain cells. When lung cells take up free serotonin, it induces bronchial contraction via stimulation of 5-HT3 and 5-HT4 postsynaptic receptors.

Tianeptine has been shown to reduce the frequency and severity of asthma attacks. And it is thought that the decrease in free serotonin may be one mechanism by which this occurs .In other clinical studies, tianeptine triggered a sudden disappearance of asthma attacks and improved pulmonary function in asthmatic children.

4. Improves symptoms associated with irritable bowel syndrome

Serotonin is a neurotransmitter in the nervous system that can also be found in the gastrointestinal tract. It controls the intestinal secretions and the movement of digestive material. Elevated levels of serotonin are believed to contribute to the symptoms of irritable bowel syndrome (IBS), including pain, bloating, and diarrhea.

Tianeptine is a medication that works by decreasing serotonergic activity. This action can improve the symptoms associated with IBS and non-ulcer dyspepsia, two conditions characterized by stomach pain and discomfort.

In a clinical trial, both tianeptine and amitriptyline have been found to be effective at treating patients suffering from IBS. However, adverse effects like constipation and dry mouth were considerably lower in patients using tianeptine. Another study revealed that tianeptine reduces symptoms related to IBS and enhances the patients’ overall quality of life.

5. Relieves pain and inflammation

While there is no concrete clinical evidence to support the use of tianeptine for pain and inflammation, there are some animal and cell-based researches that suggest it may be effective.

For example, one study found that tianeptine was able to reduce neuropathic pain in rats. Another study on rats suggests that tianeptine might effectively manage neuropathic pain. Also, ts analgesic mechanism is at the spinal level.

Similarly, a study found that tianeptine has anti-inflammatory effects on microglial cells. Moreover, tianeptine sodium salt may help prevent cancer cell invasion and potentially improve outcomes for cancer patients.

While these studies are promising, they are far from conclusive. More research is needed to conclude if tianeptine is effective for pain and inflammation in humans. However, the existing body of evidence should guide future investigational efforts.

Risks Involved

Just like taking any medication, you need to consider the risks of tianeptine before using it.

Tianeptine addiction and poisoning

Over the past decade, there was a rapid increase in the use of tianeptine. While tianeptine appears to effectively treat depression, it can also be abused.

When taken in large doses, tianeptine produces feelings of euphoria and pleasurable sensations similar to heroin and other opioids. As a result, it is among the most popular drug of abuse.

In fact, from 2000 to 2017, the number of tianeptine-related poison control center calls rapidly and markedly increased in the United States, according to a review of data from the National Poison Data System (NPDS) by the Centers for Disease Control and Prevention (CDC).

Tianeptine is an atypical antidepressant not approved for use in the United States. However, it is readily available online as a dietary supplement and has been associated with serious adverse effects. It can be very addictive, leading to severe withdrawal symptoms, especially for former opiate consumers.

There is truly a risk of tianeptine abuse and dependence. As such, patients must be monitored closely if they are prescribed tianeptine. Those with a history of drug or alcohol dependence are particularly at risk. The benefits of the prescription must also be carefully assessed in these cases.As a mu-opioid receptor agonist, tianeptine might have the same addiction withdrawal tendencies as a typical opiate. However, like any person looking to discontinue antidepressant medication, daily users of tianeptine have to slowly taper their dosages instead of abruptly stopping. This will ensure that discontinuation side effects are kept to a bare minimum.

Liver injury

It is well-established that antidepressant drugs can cause drug-induced liver injury (DILI). The mechanism by which these drugs cause DILI is not fully understood. However, it is believed to be associated with the metabolism of the drugs by the liver. Clinical data on antidepressant-induced liver injury is limited. But a few case reports and case series suggest that this type of drug-induced liver injury is more likely to occur in patients taking high doses of the drugs or who have other risk factors for liver damage.

Antidepressants are associated with a range of risks, including hepatotoxicity or liver damage. The antidepressants most likely to cause hepatotoxicity are tianeptine, iproniazid, nefazodone, phenelzine, imipramine, duloxetine, bupropion, amitriptyline, trazodone, and agomelatine. Those with the least potential for hepatotoxicity are paroxetine, escitalopram, citalopram, and fluvoxamine.

Cross-toxicity has been described for tetracyclic and tricyclic antidepressant agents. This means that taking one of these medications may increase the risk of liver damage if you are also taking another antidepressant. If you are taking an antidepressant, be aware of the potential risks. Most importantly, speak with your doctor if you have any concerns.

How to Use

Despite its many potential uses, tianeptine should only be administered orally. Sublingual tianeptine administration should be avoided because sodium salt can peel skin in your mouth. The sulfate salt can also cause tongue infection. Tianeptine has a disturbed acid profile. And this can contribute to yeast growth in both cases.

When taken orally, tianeptine is generally safe and effective. However, it is crucial to speak with a doctor before starting any new medication, as risks may be involved.

You should never think of snorting or smoking tianeptine, whether in the sulfate or sodium form. Abuse is real and strongly discouraged.

Tianeptine can be taken with or without food, but it is important to take the drug 20 minutes before eating to ensure that it is absorbed properly.


  • Tianeptine sulfate – Dosage varies from one person to another, but 40 mg is enough to experience the effect of this drug. Due to its long onset, the sulfate form of tianeptine is used for therapeutic circumstances.
  • Tianeptine sodium – Dosage is from 15 to 100 mg. The minimum dosage will let the patient feel any effects. Meanwhile, the maximum dosage produces opioid-like effects.

For both forms of tianeptine, don’t take more than 300 mg in a day or not over 100 mg at once.

If you missed a dose, don’t worry! Just go ahead and take it as soon as possible. But if it’s more than half of the time until your next dose, skip the missed dose. Do not take two separate doses at once.


Before taking tianeptine, inform your physician if:

  • You are pregnant or breastfeeding. Or you’re planning to get pregnant.
  • You have sensitivities to any of the drug’s ingredients.
  • You will undergo an operation that requires general anesthesia.
  • You have ever had allergies to other drugs, kidney or heart disease, been unable to ingest sugars, intestinal conditions, or other mental health conditions like mania and bipolar disorder.
  • You had a history of suicidal behavior. Taking tianeptine will increase your risk of developing suicidal thoughts.

Common side effects and tips to deal with them

  • Nausea – Take it with or after food. Avoid spicy and fatty food. And follow small but frequent meals.
  • Dry mouth – Suck on ice chips, chew sugar-free gum, or sip water regularly.
  • Tiredness or drowsiness – Avoid joining activities requiring concentration or driving. Speak to your physician if you can take the drug at a different time of the day.
  • Dizziness – Make it a habit to get up from lying down or sitting position.
  • Constipation – Increase your water intake. Exercise regularly and eat fiber-rich foods.

NOTE: Most of these side effects will improve with time. But if they get worse or affect your day-to-day life, speak with your doctor.

Other important considerations

  • Avoid alcohol consumption when taking this medication. This may cause you to feel drowsy, increase anxiety, and worsen your symptoms.
  • Avoid taking other over-the-counter drugs, Chinese medicine, herbal remedies, or supplements. Tianeptine may interact with these medications.
  • Store tianeptine in a dry, cool place and away from direct sunlight. Also, keep it away from children.
  • If you must throw tianeptine away, do it safely. Pack it into a trash bag and seal it tightly before tossing it in the bin.
  • Never stop taking tianeptine on your own without speaking with your physician.

When to Call a Doctor

Stop taking your medication and contact/see your doctor immediately as soon as you notice or feel any of these signs and symptoms.

  • Symptoms of drug allergy like difficulty in breathing, swollen lips, eyes, tongue, or face, and itchy skin rashes
  • Signs and symptoms of liver problem like yellowing of eyes or skin, dark brown urine, clay-colored stools, and stomachache
  • Chest pain
  • Irregular, pounding, or fast heartbeat
  • Difficulty passing urine
  • Severe muscle ache
  • Blurred vision

NOTE: Seek immediate medical advice if you take more than your recommended dose.

Key Takeaways

Tianeptine is a powerful antidepressant with unique properties and a host of potential benefits. It can help those suffering from depression, stress, anxiety, asthma, IBS, and even post-traumatic stress disorder. It’s also associated with a few risks. Thus, it’s important to understand how to use it safely and effectively before you start taking it.

If you decide that tianeptine is right for you, buy only from reputable sources. Here at Tianeptine Supply, we offer the highest quality yet affordable tianeptine. We also provide a certificate of analysis indicating 98% or higher purity. Don’t waste time and money on inferior brands. Shop from us today!