Tianeptine Sulfate: Benefits & Usage

Tianeptine is an atypical antidepressant that has unique clinical pharmacology. It increases levels of serotonin and norepinephrine in the brain. It also has antioxidant and anti-inflammatory effects. It is effective in treating depression, even in elderly patients with recurrent major depressive disorder. It can improve mood, cognitive function, and energy levels. It is also effective in treating insomnia, anxiety, and pain.

Tianeptine has two forms, Tianeptine Sodium and Tianeptine Sulfate. The main difference between the two depends on how your body absorbs it. Weighing out several essential factors before deciding may help determine which form would work best for someone’s needs. However, even if they have similar side effects, both formulations still provide beneficial purposes such as boosting moods or improving focus/memory.

If you are looking for a way to improve your major depressive disorder symptoms and irritable bowel syndrome (IBS), try tianeptine sulfate. It could be your best option. This new drug has been shown to be effective in both reducing depressive symptoms and improving bowel function.

Learn more about how it works, including its benefits and usage below.


What Does Tianeptine Do to the Body?

Tianeptine is a medication that is used for treating depression. The exact mechanism of action of tianeptine is not yet fully understood. But it is thought to work by increasing the levels of serotonin in the brain. This can help to improve mood and alleviate symptoms of depression. It also reduces stress-induced atrophy of neuronal dendrites by boosting cellular uptake for this important neurotransmitter.

Unlike most tricyclic antidepressants, it does not appear to have any adverse effects on cognitive function or psychomotor performance. That is why tianeptine has more advantages over traditional treatment options.

Moreover, antidepressant tianeptine does not undergo first-pass metabolism, unlike other medications. This means that it can enter your bloodstream faster and reach those targeted areas of your brain quicker. It also carries with it an excellent bioavailability rate. That means a single oral capsule should give good results even when taken with food. Finally, it can rapidly be excreted from the body by the kidney.

Tianeptine Sulfate vs. Tianeptine Sodium

Tianeptine sodium is a quick-acting agent that provides an initial boost in mood and focus. However, it doesn’t last very long. On the other hand, tianeptine sulfate has longer onset times. That means sustained improvements over time and improved mental clarity for those who use them.

Here’s how each form is metabolized by the body:

The sodium form is a fast-acting version of tianeptine. It has been designed to provide an improved mood quickly and efficiently. It does so by linking up with chemical bonds in your body, breaking them down rapidly. But this also means these effects will wear off much quicker than if you were taking a tianeptine sulfate dosage.

Tianeptine sulfate is an improved version of tianeptine sodium. It needs to be broken down by the liver before being released into your body. It also has a longer onset time. That means you will feel its effects more slowly. But the beneficial effects are still noticeable and can last for up 2-4 hours compared with most other types of antidepressant drugs, whose side effects usually peak within 1 day and then wear off after 3 weeks. The release pattern over twelve hours makes the sulfate form steadier. It provides subtle improvements throughout each dosage level rather than spikes at every dose.

4 Main Benefits & Usage

Tianeptine is an effective antidepressant drug, but it has many other benefits as well.

1. Relieves depressive symptoms

Tianeptine is a drug that has been shown to have powerful anti-depressant and anxiolytic effects. These characteristics were discovered across many human clinical trials, along with animal and cellular studies.

Tianeptine has been found to be just as effective at treating major depressive disorder when compared to traditional anti-depressants. It also seems like it works better in patients who had trouble getting relief from their previous treatments and those taking the drug for long periods of time. They claim to experience fewer frequency rates of relapse or reoccurrence of depression symptoms over time.

Moreover, tianeptine is a medication that has been shown to help with anxiety-related disorders such as panic attacks and post-traumatic stress disorder (PSTD). The results from two clinical trials show how it can block the occurrence of these conditions in patients. Another trial supports its effectiveness for those who suffer from PSTD by showing significant improvement in symptoms when taken regularly over time. These findings are supported not only by animal model data but also by human studies providing evidence about tianeptine’s ability to block stressful events before they happen or reduce emotional responses after experiencing them.

2. Improves mood-related disorders

There are several mechanisms by which tianeptine may alter brain function to improve mood-related disorders.

Glutamate stabilization

Tianeptine has been shown to regulate the glutamatergic system in various brain areas. Studies have found that this drug can prevent stress-induced increases of glutamate at locations associated with emotion, reward, and fear processing, such as within the amygdala.

Tianeptine has been shown to protect against the reorganization of glutamatergic vesicles at synapses in rats. This indicates tianeptine can actually prevent mood disorders. That is because tianeptine appears to regulate excitatory-inhibitory balance within our brains, which is vital for healthy function.

Adenosine receptors’ activation

Tianeptine may help relieve anxiety by activating the adenosine A1 receptor subunit. This can lead to a reduction in heart rate, which lowers physical symptoms associated with panic and agoraphobia without eliminating internal thoughts or emotions completely.

BDNF restoration

Tianeptine has been shown to regulate a vital neuronal growth factor, brain-derived neurotrophic factor (BDNF). BDNF is critical in regulating cell survival and plasticity throughout the central nervous system. Studies have found that acute stressors decrease levels of this important neurochemical while chronic worries increase it. That is possibly the same explanation for how tianeptine can improve learning abilities.

3. Treats Irritable Bowel Syndrome

Serotonin is a vital neurotransmitter in the nervous system of the gut, where it controls secretions and movement. When there’s too much serotonin, people may suffer from pain or bloating along with diarrhea. This medical condition is called irritable bowel syndrome (IBS). Tianeptine is an effective treatment for IBS and non-ulcer dyspepsia because it decreases serotonergic activity.

In a randomized comparative study regarding the efficacy of tianeptine versus escitalopram in patients with IBS, it revealed that tianeptine is as effective, if not more so than escitalopram. This study shows that tianeptine is effective at treating IBS patients with psychiatric comorbidities like anxiety and depression. This drug can be a promising new treatment for these conditions. So it’s important to learn more about its side effects in order to best help people suffering from IBS. Another comparative study revealed that the efficacy and tolerability of tianeptine for treating IBS had been found to be comparable with amitriptyline.

4. Controls asthma attacks

Tianeptine is a drug that can be used to treat asthma. It works by enhancing serotonin uptake into platelets and serotonergic axons in the brain. As a result, it provokes a rapid disappearance of asthma attacks. This explains why tianeptine is a powerful therapeutic tool in controlling asthma.

Another study revealed that tianeptine is an effective treatment for bronchial asthma. It hinders the occurrence and severity of attacks. It works by increasing levels of serotonin, which helps to regulate breathing patterns in some people with this condition. It also triggers absolute cessation from having any more episodes within 30-60 minutes after oral intake.

How to Use Tianeptine Sulfate.

Tianeptine is available in capsule or powder form to take orally. Sublingual use can lead to peeling of the skin around your mouth and tongue. Thus, it should never be taken sublingually. When taken orally as a pill, it will provide consistent results.

Important Note: The Tianeptine sulfate could lead to an infection growing on your tongue. The drug’s acidic profile can also cause yeast infections in some people.


The typical dosage for tianeptine sulfate varies depending upon the person. But 40 milligrams should provide more than enough of this drug’s capabilities in any given situation – especially since its onset has been noted as being quite long-lasting.

Doctors might prescribe therapeutic levels to treat chronic depression disorders with low response rates or inadequate relief after two weeks of usage. However, some risks are associated with taking tianeptine capsules over extended periods.

Side Effects

Tianeptine comes with some potential side effects. But it’s not as severe as compared to other prescription medications.

The most common side effects that people have reported include things like diarrhea, constipation, vomiting, and changes in appetite. Some people have trouble sleeping, and it causes them either fatigue or insomnia. Others experience things like blurred vision, dizziness, rashes, and headaches.

Drug Interactions

The side effects of this drug may be mild. However, you should still make sure not to mix it with anything else because the risk is too great. When other antidepressants are involved, they could cause an unforeseen reaction that may result in death.

Tramadol is the only confirmed dangerous drug interaction. But it is always best for you to check with your doctor before starting any new medications.

Tolerance and Addiction

Tianeptine has been found to have opioid-like euphoria. Thus, it could be addictive. Also, it should not be used recreationally due to its potential for abuse.

After prolonged use, the variety of effects will likely lead to tolerance. It will take more than one dose per day for an effect. It can also take 2 weeks or longer before reaching baseline levels again if taking a break from using this medication altogether. It seems like there’s also cross-tolerance with any tricyclic antidepressant.

Chronic use of tianeptine may lead to physical and psychological dependence. When this happens, withdrawal symptoms will occur if the patient stops taking this drug. So like any person looking to discontinue antidepressant medication, daily users of tianeptine must have their dosage slowly tapered instead of abruptly stopping. This will not just reduce the risk of side effects when quitting but also ensure safe withdrawal management.

Tianeptine withdrawal is no walk in the park. And it can occur at a dosage of as little as 500 mg daily. But the severity will increase with the length of usage or quantity consumed.  Symptoms may include watery eyes, emotional disturbance, dry heaves, flu-like, and breath instability.

Key Takeaways

Tianeptine Sulfate is a derivative of tianeptine that has many benefits for the body. Studies have shown to relieve depression symptoms, reduce anxiety, improve mood, treat irritable bowel syndrome, and control asthma attacks.

Tianeptine comes in powder and capsule form, making it easy to use. Over the years, tianeptine has become accessible for self-medication after learning about its benefits. But remember that there are also risks associated with abuse that should be considered before taking this powerful medication alone. Supervision from experts who know what they’re doing is a must.

So before trying this drug, don’t just equip yourself with all the pertinent information about how to take Tianeptine safely. You must also consult a health care professional and talk about how it can help improve your quality of life.

If you’re ready to enjoy all the beneficial effects of this drug, buy Tianeptine from us. We offer high-quality Tianeptine sulfate and sodium at competitive prices.